- 8th-6th century: The Oscan people, an Italic tribe, are believed to be the first to settle in the area around the 8th century BC.
- 6th-4th century BC: The Etruscans, another powerful civilization, likely exerted influence over the region during this period. In the 6th century, the Greeks took over and established a trading post named Heraklion, due to the town's strategic location on the Bay of Naples. The Samnites, another Italic people, gained control of Herculaneum in the 4th century BC.
- 89 BC - 79 AD: Following the Social War between Rome and the Italic groups, Rome takes over Herculaneum, granting its male population Roman citizenship. The town adopts a Roman layout and institutions.